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Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody

Checkpoint immunotherapy antibodies have not shown efficacy in pancreatic adenocarcinoma. Pre-clinical studies and subsequently an on-going phase I trial have demonstrated the safety and efficacy of combinatorial radio-chemotherapy plus surgery in this malignancy, including the combination of sorafe...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Booth, Laurence, Roberts, Jane Lisa, Poklepovic, Andrew, Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343728/
https://ncbi.nlm.nih.gov/pubmed/30142009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1507258
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