Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases CCR7 Expression in Plaque Macrophages

BACKGROUND—: We previously showed that mice lacking LDL receptor-related protein 1 in macrophages (MΦLRP1(−/−)) undergo accelerated atherosclerotic plaque formation due to changes in macrophages including increased apoptosis, decreased efferocytosis, and exaggerated transition to the inflammatory M1...

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Bibliografske podrobnosti
izdano v:Circulation
Main Authors: Mueller, Paul A., Zhu, Lin, Tavori, Hagai, Huynh, Katherine, Giunzioni, Ilaria, Stafford, John M., Linton, MacRae F., Fazio, Sergio
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343494/
https://ncbi.nlm.nih.gov/pubmed/29794082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.031702
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