Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease

BACKGROUND: Identifying effective strategies to prevent memory loss in AD has eluded researchers to date, and likely reflects insufficient understanding of early pathogenic mechanisms directly affecting memory encoding. As synaptic loss best correlates with memory loss in AD, refocusing efforts to i...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Chakroborty, Shreaya, Hill, Evan S., Christian, Daniel T., Helfrich, Rosalind, Riley, Shannon, Schneider, Corinne, Kapecki, Nicolas, Mustaly-Kalimi, Sarah, Seiler, Figen A., Peterson, Daniel A., West, Anthony R., Vertel, Barbara M., Frost, William N., Stutzmann, Grace E.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343260/
https://ncbi.nlm.nih.gov/pubmed/30670054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0307-7
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