Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

Alzheimer's disease (AD)-linked presenilin (PS) mutations result in pronounced endoplasmic reticulum calcium disruptions that occur before detectable histopathology and cognitive deficits. More subtly, these early AD-linked calcium alterations also reset neurophysiological homeostasis, such tha...

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Main Authors: Chakroborty, Shreaya, Kim, Joyce, Schneider, Corinne, Jacobson, Christopher, Molgó, Jordi, Stutzmann, Grace E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417348/
https://ncbi.nlm.nih.gov/pubmed/22699914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0936-12.2012
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