Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

Fifty percent of inner ear disorders are caused by genetic mutations. To develop treatments for genetic inner ear disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding sequence for Transmembrane Channel-Like (Tmc) 1 or 2 into sensory h...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Nist-Lund, Carl A., Pan, Bifeng, Patterson, Amy, Asai, Yukako, Chen, Tianwen, Zhou, Wu, Zhu, Hong, Romero, Sandra, Resnik, Jennifer, Polley, Daniel B., Géléoc, Gwenaelle S., Holt, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342993/
https://ncbi.nlm.nih.gov/pubmed/30670701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08264-w
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