Bulk tissue cell type deconvolution with multi-subject single-cell expression reference

Knowledge of cell type composition in disease relevant tissues is an important step towards the identification of cellular targets of disease. We present MuSiC, a method that utilizes cell-type specific gene expression from single-cell RNA sequencing (RNA-seq) data to characterize cell type composit...

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Vydáno v:Nat Commun
Hlavní autoři: Wang, Xuran, Park, Jihwan, Susztak, Katalin, Zhang, Nancy R., Li, Mingyao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342984/
https://ncbi.nlm.nih.gov/pubmed/30670690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08023-x
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