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The neurotoxic secreted phospholipase A(2) from the Vipera a. ammodytes venom targets cytochrome c oxidase in neuronal mitochondria
The β-neurotoxic secreted phospholipases A(2) (sPLA(2)s) block neuro-muscular transmission by poisoning nerve terminals. Damage inflicted by such sPLA(2)s (β-ntx) on neuronal mitochondria is characteristic, very similar to that induced by structurally homologous endogenous group IIA sPLA(2) when its...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6342964/ https://ncbi.nlm.nih.gov/pubmed/30670719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36461-6 |
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