TLR signaling is activated in lymph-node resident CLL cells and is only partially inhibited by ibrutinib

Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells driven by B-cell receptor (BCR) signaling and activated primarily in the lymph node. The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib effectively inhibits BCR-dependent proliferation and survival signals and has emerged as a...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Dadashian, Eman L., McAuley, Erin M., Liu, Delong, Shaffer, Arthur L., Young, Ryan M., Iyer, Jessica R., Kruhlak, Michael J., Staudt, Louis M., Wiestner, Adrian, Herman, Sarah E. M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342512/
https://ncbi.nlm.nih.gov/pubmed/30498085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0781
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