Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL

Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental factors for proliferation and survival. In particular, tissue-resident CLL cells show prominent activation of both B-cell receptor (BCR) and NF-κB pathways. We evaluated the in vivo effects of ibrutinib, a Bruton tyrosine kinase (...

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Detalhes bibliográficos
Main Authors: Herman, Sarah E. M., Mustafa, Rashida Z., Gyamfi, Jennifer A., Pittaluga, Stefania, Chang, Stella, Chang, Betty, Farooqui, Mohammed, Wiestner, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046423/
https://ncbi.nlm.nih.gov/pubmed/24659631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-548610
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