Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures

Regulator of G protein signaling (RGS) proteins temporally regulate heterotrimeric G protein signaling cascades elicited by GPCR activation, and thus are essential for cell homeostasis. The dysregulation of RGS protein expression has been linked to several pathologies, spurring discovery efforts to...

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Detaylı Bibliyografya
Yayımlandı:SLAS Discov
Asıl Yazarlar: Bodle, Christopher R., Schamp, Josephine H., O’Brien, Joseph B., Hayes, Michael P., Wu, Meng, Doorn, Jonathan A., Roman, David L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342279/
https://ncbi.nlm.nih.gov/pubmed/29351497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217752301
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