Combinatorial Screening Using Orthotopic Patient Derived Xenograft-Expanded Early Phase Cultures of Osteosarcoma Identify Novel Therapeutic Drug Combinations

Lead discovery in osteosarcoma has been hampered by the lack of new agents, limited representative clinical samples and paucity of accurate preclinical models. We developed orthotopic patient-derived xenografts (PDXs) that recapitulated the molecular, cellular and histologic features of primary tumo...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Loh, Amos H.P., Stewart, Elizabeth, Bradley, Cori L., Chen, Xiang, Daryani, Vinay, Stewart, Clinton F., Calabrese, Christopher, Funk, Amy, Miller, Greg, Karlstrom, Asa, Krafcik, Fred, Goshorn, David R., Vogel, Peter, Bahrami, Armita, Shelat, Anang, Dyer, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342199/
https://ncbi.nlm.nih.gov/pubmed/30395907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.10.033
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