Combinatorial Screening Using Orthotopic Patient Derived Xenograft-Expanded Early Phase Cultures of Osteosarcoma Identify Novel Therapeutic Drug Combinations

Lead discovery in osteosarcoma has been hampered by the lack of new agents, limited representative clinical samples and paucity of accurate preclinical models. We developed orthotopic patient-derived xenografts (PDXs) that recapitulated the molecular, cellular and histologic features of primary tumo...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cancer Lett
मुख्य लेखकों: Loh, Amos H.P., Stewart, Elizabeth, Bradley, Cori L., Chen, Xiang, Daryani, Vinay, Stewart, Clinton F., Calabrese, Christopher, Funk, Amy, Miller, Greg, Karlstrom, Asa, Krafcik, Fred, Goshorn, David R., Vogel, Peter, Bahrami, Armita, Shelat, Anang, Dyer, Michael A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2018
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342199/
https://ncbi.nlm.nih.gov/pubmed/30395907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.10.033
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