Comprehensive analysis of chromatin states in atypical teratoid/rhabdoid tumor identifies diverging roles for SWI/SNF and Polycomb in gene regulation

Biallelic inactivation of SMARCB1, encoding a member of the SWI/SNF chromatin remodeling complex, is the hallmark genetic aberration of atypical teratoid rhabdoid tumors (ATRT). Here, we report how loss of SMARCB1 affects the epigenome in these tumors. Using ChIP-sequencing on primary tumors for a s...

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Publicado en:Cancer Cell
Autores principales: Erkek, Serap, Johann, Pascal D., Finetti, Martina A., Drosos, Yiannis, Chou, Hsien-Chao, Zapatka, Marc, Sturm, Dominik, Jones, David T.W., Korshunov, Andrey, Rhyzova, Marina, Wolf, Stephan, Mallm, Jan-Philipp, Beck, Katja, Witt, Olaf, Kulozik, Andreas E., Frühwald, Michael C., Northcott, Paul A., Korbel, Jan O., Lichter, Peter, Eils, Roland, Gajjar, Amar, Roberts, Charles W.M., Williamson, Daniel, Hasselblatt, Martin, Chavez, Lukas, Pfister, Stefan M., Kool, Marcel
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341227/
https://ncbi.nlm.nih.gov/pubmed/30595504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.11.014
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