Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression

Alterations of the 5-HT(1A) receptor and BDNF have consistently been associated with affective disorders. Two functional single nucleotide polymorphisms (SNPs), rs6295 of the serotonin 1A receptor gene (HTR1A) and rs6265 of brain-derived neurotrophic factor gene (BDNF), may impact transcriptional re...

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Udgivet i:Transl Psychiatry
Main Authors: Kautzky, Alexander, James, Gregory M., Philippe, Cecile, Baldinger-Melich, Pia, Kraus, Christoph, Kranz, Georg S., Vanicek, Thomas, Gryglewski, Gregor, Hartmann, Annette M., Hahn, Andreas, Wadsak, Wolfgang, Mitterhauser, Markus, Rujescu, Dan, Kasper, Siegfried, Lanzenberger, Rupert
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341100/
https://ncbi.nlm.nih.gov/pubmed/30664620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0308-2
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