Genetic ablation of Rbm38 promotes lymphomagenesis in the context of mutant p53 by downregulating PTEN

Mutant p53 exerts gain-of-function effects that drive metastatic progression and therapeutic resistance, but the basis for these effects remain obscure. The RNA binding protein RBM38 limits translation of mutant p53 and is often ablated in tumors harboring it. Here we show how loss of Rbm38 signific...

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Publicado en:Cancer Res
Main Authors: Zhang, Jin, Xu, Enshun, Ren, Cong, Yang, Hee Jung, Zhang, Yanhong, Sun, Wenqiang, Kong, Xiangmudong, Zhang, Weici, Chen, Mingyi, Huang, Eric, Chen, Xinbin
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340497/
https://ncbi.nlm.nih.gov/pubmed/29330147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2457
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