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The Rbm38-p63 Feedback Loop Is Critical for Tumor Suppression and Longevity
The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop. To investigate the biological significance of the Rbm38-p63 loop in vivo, a cohort of WT, Rbm38(−/−), TAp63(+/−) and Rbm38(−...
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| Publicado no: | Oncogene |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5970038/ https://ncbi.nlm.nih.gov/pubmed/29520104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0176-5 |
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