Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium

In mammals, all-trans retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH) present in both Sertoli cells (SCs) and germ cells (GCs). In order to determine the relative contributions of each source of ATRA, we have generated mice lacki...

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Библиографические подробности
Опубликовано в: :Development
Главные авторы: Teletin, Marius, Vernet, Nadège, Yu, Jianshi, Klopfenstein, Muriel, Jones, Jace W., Féret, Betty, Kane, Maureen A., Ghyselinck, Norbert B., Mark, Manuel
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Ltd 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340151/
https://ncbi.nlm.nih.gov/pubmed/30487180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.170225
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