Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium

In mammals, all-trans retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH) present in both Sertoli cells (SCs) and germ cells (GCs). In order to determine the relative contributions of each source of ATRA, we have generated mice lacki...

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Veröffentlicht in:Development
Hauptverfasser: Teletin, Marius, Vernet, Nadège, Yu, Jianshi, Klopfenstein, Muriel, Jones, Jace W., Féret, Betty, Kane, Maureen A., Ghyselinck, Norbert B., Mark, Manuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340151/
https://ncbi.nlm.nih.gov/pubmed/30487180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.170225
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