Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium

In mammals, all-trans retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH) present in both Sertoli cells (SCs) and germ cells (GCs). In order to determine the relative contributions of each source of ATRA, we have generated mice lacki...

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Detalhes bibliográficos
Publicado no:Development
Principais autores: Teletin, Marius, Vernet, Nadège, Yu, Jianshi, Klopfenstein, Muriel, Jones, Jace W., Féret, Betty, Kane, Maureen A., Ghyselinck, Norbert B., Mark, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340151/
https://ncbi.nlm.nih.gov/pubmed/30487180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.170225
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