Pharmacokinetic–pharmacodynamic modelling of platelet response to ticagrelor in stable coronary artery disease and prior myocardial infarction patients

AIMS: To characterize ticagrelor exposure‐response relationship for platelet inhibition in patients with stable coronary artery disease (CAD) and a history of myocardial infarction (MI), using nonlinear mixed effects modelling and simulation. METHODS: Platelet function data were integrated with plas...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Åstrand, Magnus, Amilon, Carl, Röshammar, Daniel, Himmelmann, Anders, Angiolillo, Dominick J., Storey, Robert F., Gurbel, Paul A., Bonaca, Marc P., Hamrén, Bengt
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339964/
https://ncbi.nlm.nih.gov/pubmed/30414387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13812
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