Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology

TAR-DNA binding protein 43 (TDP-43) aggregation is the most common pathological hallmark in frontotemporal dementia (FTD) and characterizes nearly all patients with motor neuron disease (MND). The earliest stages of TDP-43 pathobiology are not well characterized, and whether neurodegeneration result...

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Publicado en:Acta Neuropathol
Autores principales: Nana, Alissa L., Sidhu, Manu, Gaus, Stephanie E., Hwang, Ji-Hye L., Li, Libo, Park, Youngsoon, Kim, Eun-Joo, Pasquini, Lorenzo, Allen, Isabel E., Rankin, Katherine P., Toller, Gianina, Kramer, Joel H., Geschwind, Daniel H., Coppola, Giovanni, Huang, Eric J., Grinberg, Lea T., Miller, Bruce L., Seeley, William W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339592/
https://ncbi.nlm.nih.gov/pubmed/30511086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1942-8
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