Reflexive Laboratory-Based Cryptococcal Antigen Screening and Preemptive Fluconazole Therapy for Cryptococcal Antigenemia in HIV-Infected Individuals With CD4 <100 Cells/µL: A Stepped-Wedge, Cluster-Randomized Trial

BACKGROUND: HIV-infected persons with cryptococcal antigenemia (CrAg) are at high risk for meningitis or death. We evaluated the effect of CrAg screening and preemptive fluconazole therapy, adjunctive to antiretroviral therapy (ART), on 6-month survival among persons with advanced HIV/AIDS. METHODS:...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Meya, David B., Kiragga, Agnes N., Nalintya, Elizabeth, Morawski, Bozena M., Rajasingham, Radha, Park, Benjamin J., Mubiru, Anthony, Kaplan, Jonathan E., Manabe, Yukari C., Boulware, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: JAIDS Journal of Acquired Immune Deficiency Syndromes 2019
Assuntos:
Clinical Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339522/
https://ncbi.nlm.nih.gov/pubmed/30399034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000001894
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