Reflexive Laboratory-Based Cryptococcal Antigen Screening and Preemptive Fluconazole Therapy for Cryptococcal Antigenemia in HIV-Infected Individuals With CD4 <100 Cells/µL: A Stepped-Wedge, Cluster-Randomized Trial

BACKGROUND: HIV-infected persons with cryptococcal antigenemia (CrAg) are at high risk for meningitis or death. We evaluated the effect of CrAg screening and preemptive fluconazole therapy, adjunctive to antiretroviral therapy (ART), on 6-month survival among persons with advanced HIV/AIDS. METHODS:...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Acquir Immune Defic Syndr
Auteurs principaux: Meya, David B., Kiragga, Agnes N., Nalintya, Elizabeth, Morawski, Bozena M., Rajasingham, Radha, Park, Benjamin J., Mubiru, Anthony, Kaplan, Jonathan E., Manabe, Yukari C., Boulware, David R.
Format: Artigo
Langue:Inglês
Publié: JAIDS Journal of Acquired Immune Deficiency Syndromes 2019
Sujets:
Clinical Science
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339522/
https://ncbi.nlm.nih.gov/pubmed/30399034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000001894
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