Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo

DICER1 gene alterations and decreased expression are associated with developmental disorders and diseases in humans. Oscillation of Dicer1 phosphorylation and dephosphorylation regulates its function during the oocyte-to-embryo transition in Caenorhabditis elegans. Dicer1 is also phosphorylated upon...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Aryal, Neeraj K., Pant, Vinod, Wasylishen, Amanda R., Parker-Thornburg, Jan, Baseler, Laura, El-Naggar, Adel K., Liu, Bin, Kalia, Awdhesh, Lozano, Guillermina, Arur, Swathi
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2019
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338878/
https://ncbi.nlm.nih.gov/pubmed/30593561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814377116
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