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Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
The platinum-based drug cisplatin is a widely used first-line therapy for several cancers. Cisplatin interacts with DNA mainly in the form of Pt-d(GpG) di-adduct, which stalls cell proliferation and activates DNA damage response. Although cisplatin shows a broad spectrum of anticancer activity, its...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6338751/ https://ncbi.nlm.nih.gov/pubmed/30659176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08290-2 |
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