Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions

We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) with fetal growth restriction (FGR). Tadalafil is a selective phosphodiesterase 5 inhibitor that dilates the maternal blood sinuses in the placenta, thereby fa...

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Pubblicato in:Sci Rep
Autori principali: Tachibana, Ryota, Umekawa, Takashi, Yoshikawa, Kento, Owa, Takao, Magawa, Shoichi, Furuhashi, Fumi, Tsuji, Makoto, Maki, Shintaro, Shimada, Kyoko, Kaneda, Michiko K., Nii, Masafumi, Tanaka, Hiroaki, Tanaka, Kayo, Kamimoto, Yuki, Kondo, Eiji, Kato, Ineko, Ikemura, Kenji, Okuda, Masahiro, Ma, Ning, Miyoshi, Takekazu, Hosoda, Hiroshi, Endoh, Masayuki, Kimura, Tadashi, Ikeda, Tomoaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338749/
https://ncbi.nlm.nih.gov/pubmed/30659198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36084-x
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