Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions

We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) with fetal growth restriction (FGR). Tadalafil is a selective phosphodiesterase 5 inhibitor that dilates the maternal blood sinuses in the placenta, thereby fa...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tachibana, Ryota, Umekawa, Takashi, Yoshikawa, Kento, Owa, Takao, Magawa, Shoichi, Furuhashi, Fumi, Tsuji, Makoto, Maki, Shintaro, Shimada, Kyoko, Kaneda, Michiko K., Nii, Masafumi, Tanaka, Hiroaki, Tanaka, Kayo, Kamimoto, Yuki, Kondo, Eiji, Kato, Ineko, Ikemura, Kenji, Okuda, Masahiro, Ma, Ning, Miyoshi, Takekazu, Hosoda, Hiroshi, Endoh, Masayuki, Kimura, Tadashi, Ikeda, Tomoaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338749/
https://ncbi.nlm.nih.gov/pubmed/30659198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36084-x
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