Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions

We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) with fetal growth restriction (FGR). Tadalafil is a selective phosphodiesterase 5 inhibitor that dilates the maternal blood sinuses in the placenta, thereby fa...

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הוצא לאור ב:Sci Rep
Main Authors: Tachibana, Ryota, Umekawa, Takashi, Yoshikawa, Kento, Owa, Takao, Magawa, Shoichi, Furuhashi, Fumi, Tsuji, Makoto, Maki, Shintaro, Shimada, Kyoko, Kaneda, Michiko K., Nii, Masafumi, Tanaka, Hiroaki, Tanaka, Kayo, Kamimoto, Yuki, Kondo, Eiji, Kato, Ineko, Ikemura, Kenji, Okuda, Masahiro, Ma, Ning, Miyoshi, Takekazu, Hosoda, Hiroshi, Endoh, Masayuki, Kimura, Tadashi, Ikeda, Tomoaki
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2019
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338749/
https://ncbi.nlm.nih.gov/pubmed/30659198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36084-x
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