RARβ acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells

This study investigates the mechanism and consequences of microRNA-22 (miR-22) induction. Our data revealed for the first time that retinoic acid (RA) and histone deacetylase (HDAC) inhibitors, including short-chain fatty acids and suberanilohydroxamic acid (SAHA), could individually or in combinati...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Hu, Ying, French, Samuel W., Chau, Thinh, Liu, Hui-Xin, Sheng, Lili, Wei, Fang, Stondell, Jesse, Garcia, Juan C., Du, Yanlei, Bowlus, Christopher L., Wan, Yu-Jui Yvonne
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338632/
https://ncbi.nlm.nih.gov/pubmed/30252536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801390R
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