HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4(+)CD8(+) thymocytes for CD4-lineage commitment

CD4 and CD8 T cells are vital components of the immune system. We found that histone deacetylase 3 (HDAC3) is critical for the development of CD4 T cells, as HDAC3-deficient DP thymocytes generate only CD8SP thymocytes in mice. In the absence of HDAC3, MHC Class II-restricted OT-II thymocytes are re...

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Publicado en:eLife
Autores principales: Philips, Rachael Laura, Lee, Jeong-Heon, Gaonkar, Krutika, Chanana, Pritha, Chung, Ji Young, Romero Arocha, Sinibaldo R, Schwab, Aaron, Ordog, Tamas, Shapiro, Virginia Smith
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Immunology and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338460/
https://ncbi.nlm.nih.gov/pubmed/30657451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43821
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