Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice

Eicosapentaenoic acid (EPA) in fish oil is known to improve hepatic steatosis. However, it remains unclear whether such action of EPA is actually caused by peroxisome proliferator-activated receptor α (PPARα) activation. To explore the contribution of PPARα to the effects of EPA itself, male wild-ty...

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Publicado en:Biochem Pharmacol
Autores principales: Tanaka, Naoki, Zhang, Xiuguo, Sugiyama, Eiko, Kono, Hiroyuki, Horiuchi, Akira, Nakajima, Takero, Kanbe, Hiroki, Tanaka, Eiji, Gonzalez, Frank J., Aoyama, Toshifumi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338080/
https://ncbi.nlm.nih.gov/pubmed/20691165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.07.031
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