ACVR1(R206H) FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification

An activating bone morphogenetic proteins (BMP) type I receptor ACVR1 (ACVR1(R206H)) mutation enhances BMP pathway signaling and causes the rare genetic disorder of heterotopic (extraskeletal) bone formation fibrodysplasia ossificans progressiva. Heterotopic ossification frequently occurs following...

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Vydáno v:Mol Biol Cell
Hlavní autoři: Haupt, Julia, Stanley, Alexandra, McLeod, Claire M., Cosgrove, Brian D., Culbert, Andria L., Wang, Linda, Mourkioti, Foteini, Mauck, Robert L., Shore, Eileen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337906/
https://ncbi.nlm.nih.gov/pubmed/30379592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-05-0311
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