Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth

The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells, favoring tumor growth. Platinum compounds are widely used as part of first line conventional cancer chemotherapy; their efficacy is however limited by per...

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Publicado en:Acta Neuropathol Commun
Autores principales: Cerles, Olivier, Gonçalves, Tânia Cristina, Chouzenoux, Sandrine, Benoit, Evelyne, Schmitt, Alain, Bennett Saidu, Nathaniel Edward, Kavian, Niloufar, Chéreau, Christiane, Gobeaux, Camille, Weill, Bernard, Coriat, Romain, Nicco, Carole, Batteux, Frédéric
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337872/
https://ncbi.nlm.nih.gov/pubmed/30657060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0657-y
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