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Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization

The retinal disease gene peripherin 2 (PRPH2) is essential for the formation of photoreceptor outer segments (OSs), where it functions in oligomers with and without its homologue ROM1. However, the precise role of these proteins in OS morphogenesis is not understood. By utilizing a knock-in mouse ex...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Conley, Shannon M, Stuck, Michael W, Watson, Jamie N, Zulliger, Rahel, Burnett, Justin L, Naash, Muna I
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337695/
https://ncbi.nlm.nih.gov/pubmed/30307502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy359
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