Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation

Alternaria alternata is a fungal allergen associated with severe asthma and asthma exacerbations. Similarly to other asthma-associated allergens, Alternaria secretes a serine-like trypsin protease(s) that is thought to act through the G protein-coupled receptor protease-activated receptor-2 (PAR(2))...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Yee, Michael C., Nichols, Heddie L., Polley, Danny, Saifeddine, Mahmoud, Pal, Kasturi, Lee, Kyu, Wilson, Emma H., Daines, Michael O., Hollenberg, Morley D., Boitano, Scott, DeFea, Kathryn A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337008/
https://ncbi.nlm.nih.gov/pubmed/30335499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00196.2018
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