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Reversal and Prevention of the Respiratory-Depressant Effects of Heroin by the Novel μ-Opioid Receptor Antagonist Methocinnamox in Rhesus Monkeys

One consequence of the ongoing opioid epidemic is a large number of overdose deaths. Naloxone reverses opioid-induced respiratory depression; however, its short duration of action limits the protection it can provide. Methocinnamox (MCAM) is a novel opioid receptor antagonist with a long duration of...

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Опубликовано в: :J Pharmacol Exp Ther
Главные авторы: Gerak, Lisa R., Maguire, David R., Woods, James H., Husbands, Stephen M., Disney, Alex, France, Charles P.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337004/
https://ncbi.nlm.nih.gov/pubmed/30463875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.253286
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