EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation

EBV latent antigen 3C (EBNA3C) is essential for EBV-induced primary B-cell transformation. Infection by EBV induces hypermethylation of a number of tumor suppressor genes, which contributes to the development of human cancers. The Ras association domain family isoform 1A (RASSF1A) is a cellular tumo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Zhang, Shengwei, Pei, Yonggang, Lang, Fengchao, Sun, Kunfeng, Singh, Rajnish Kumar, Lamplugh, Zachary L., Saha, Abhik, Robertson, Erle S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336319/
https://ncbi.nlm.nih.gov/pubmed/30615685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007514
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados