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Discovery of a 3,4,5-trisubstituted-1,2,4-triazole agonist with high affinity and selectivity at the somatostatin subtype-4 (sst(4)) receptor
A series of compounds containing a 1,2,4-triazole moiety were synthesized, targeting the somatostatin receptor subtype-4 (sst(4)). Compounds were developed in which the Phe(6)/Phe(7)/Phe(11), Trp(8), and Lys(9) mimetic groups were interchanged at positions 3, 4, and 5 of the 1,2,4-triazole ring. The...
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| Udgivet i: | Medchemcomm |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Royal Society of Chemistry
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6336083/ https://ncbi.nlm.nih.gov/pubmed/30746066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00388b |
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