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A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E
We report on the synthesis, in vitro and in vivo biological evaluations of a dimeric β-glucuronidase-responsive albumin-binding prodrug designed for the double release of MMAE upon a single enzymatic activation step. This prodrug produced a significant antitumour activity in mice bearing subcutaneou...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6335994/ https://ncbi.nlm.nih.gov/pubmed/30746064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00466h |
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