A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E

We report on the synthesis, in vitro and in vivo biological evaluations of a dimeric β-glucuronidase-responsive albumin-binding prodrug designed for the double release of MMAE upon a single enzymatic activation step. This prodrug produced a significant antitumour activity in mice bearing subcutaneou...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Renoux, Brigitte, Fangous, Laure, Hötten, Camille, Péraudeau, Elodie, Eddhif, Balkis, Poinot, Pauline, Clarhaut, Jonathan, Papot, Sébastien
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335994/
https://ncbi.nlm.nih.gov/pubmed/30746064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00466h
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