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A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E
We report on the synthesis, in vitro and in vivo biological evaluations of a dimeric β-glucuronidase-responsive albumin-binding prodrug designed for the double release of MMAE upon a single enzymatic activation step. This prodrug produced a significant antitumour activity in mice bearing subcutaneou...
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| 出版年: | Medchemcomm |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Royal Society of Chemistry
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6335994/ https://ncbi.nlm.nih.gov/pubmed/30746064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00466h |
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