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Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

Polyketide–polyketide hybrids are unique natural products with promising bioactivity, but the hybridization processes remain poorly understood. Herein, we present that the biosynthetic pathways of two immunosuppressants, dalmanol A and acetodalmanol A, result from an unspecific monooxygenase trigger...

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Bibliografski detalji
Izdano u:Chem Sci
Glavni autori: Zhou, Zhen Zhen, Zhu, Hong Jie, Lin, Li Ping, Zhang, Xuan, Ge, Hui Ming, Jiao, Rui Hua, Tan, Ren Xiang
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2018
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335865/
https://ncbi.nlm.nih.gov/pubmed/30746075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc03697g
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