GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation

Heterozygous de novo mutations in GATA6 are the most frequent cause of pancreatic agenesis in humans. In mice, however, a similar phenotype requires the biallelic loss of Gata6 and its paralog Gata4. To elaborate the human-specific requirements for GATA6, we chose to model GATA6 loss in vitro by com...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Chia, Crystal Y., Madrigal, Pedro, Denil, Simon L.I.J., Martinez, Iker, Garcia-Bernardo, Jose, El-Khairi, Ranna, Chhatriwala, Mariya, Shepherd, Maggie H., Hattersley, Andrew T., Dunn, N. Ray, Vallier, Ludovic
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335596/
https://ncbi.nlm.nih.gov/pubmed/30629940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.12.003
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