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GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling

GATA4 and GATA6 are zinc finger transcription factors that have important functions in several mesodermal and endodermal organs, including heart, liver and pancreas. In humans, heterozygous mutations of either factor are associated with pancreatic agenesis; however, homozygous deletion of both Gata4...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Xuan, Shouhong, Sussel, Lori
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813334/
https://ncbi.nlm.nih.gov/pubmed/26932670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.127217
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