Deep Sequencing of the Mitochondrial Genome Reveals Common Heteroplasmic Sites in NADH Dehydrogenase Genes

Increasing evidence implicates mitochondrial dysfunction in aging and age-related conditions. But little is known about the molecular basis for this connection. A possible cause may be mutations in the mitochondrial DNA (mtDNA), which are often heteroplasmic – the joint presence of different alleles...

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Bibliographic Details
Published in:Hum Genet
Main Authors: Liu, Chunyu, Fetterman, Jessica L., Liu, Poching, Luo, Yan, Larson, Martin G., Vasan, Ramachandran S., Zhu, Jun, Levy, Daniel
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335583/
https://ncbi.nlm.nih.gov/pubmed/29423652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-018-1873-4
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