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Induction of pluripotent stem cells by defined factors is greatly improved by small molecule compounds
Reprogramming of mouse and human somatic cells can be achieved by ectopic expression of transcription factors, but with low efficiencies. We report that DNA methyltransferase and histone deacetylase (HDAC) inhibitors improve reprogramming efficiency. In particular, valproic acid (VPA), an HDAC inhib...
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| Publicado en: | Nat Biotechnol |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6334647/ https://ncbi.nlm.nih.gov/pubmed/18568017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1418 |
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