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Induction of pluripotent stem cells by defined factors is greatly improved by small molecule compounds

Reprogramming of mouse and human somatic cells can be achieved by ectopic expression of transcription factors, but with low efficiencies. We report that DNA methyltransferase and histone deacetylase (HDAC) inhibitors improve reprogramming efficiency. In particular, valproic acid (VPA), an HDAC inhib...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Huangfu, Danwei, Maehr, René, Guo, Wenjun, Eijkelenboom, Astrid, Snitow, Melinda, Chen, Alice E., Melton, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334647/
https://ncbi.nlm.nih.gov/pubmed/18568017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1418
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