Formate–nitrite transporters carrying nonprotonatable amide amino acids instead of a central histidine maintain pH-dependent transport

Microbial formate–nitrite transporter-type proteins (FNT) exhibit dual transport functionality. At neutral pH, electrogenic anion currents are detectable, whereas upon acidification transport of the neutral, protonated monoacid predominates. Physiologically, FNT-mediated proton co-transport is vital...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Helmstetter, Folknand, Arnold, Philipp, Höger, Bastian, Petersen, Lea Madlen, Beitz, Eric
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333897/
https://ncbi.nlm.nih.gov/pubmed/30455351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006340
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