Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase

SOX2 is a dose-dependent master stem cell protein that controls the self-renewal and pluripotency or multipotency of embryonic stem (ES) cells and many adult stem cells. We have previously found that SOX2 protein is monomethylated at lysine residues 42 and 117 by SET7 methyltransferase to promote SO...

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Foilsithe in:J Biol Chem
Main Authors: Zhang, Chunxiao, Leng, Feng, Saxena, Lovely, Hoang, Nam, Yu, Jiekai, Alejo, Salvador, Lee, Logan, Qi, Dandan, Lu, Fei, Sun, Hong, Zhang, Hui
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2019
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333883/
https://ncbi.nlm.nih.gov/pubmed/30442713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005336
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