Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice

Background: Idebenone is an antioxidant and a coenzyme Q10 analog that has been used to treat neurodegeneration disease. Some studies show idebenone exerts anti-inflammatory effects. However, whether idebenone can be used to reduce the neuroinflammation in Parkinson’s disease (PD) has been little st...

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Veröffentlicht in:Front Cell Neurosci
Hauptverfasser: Yan, Aijuan, Liu, Zhihua, Song, Lu, Wang, Xijin, Zhang, Yu, Wu, Na, Lin, Jingya, Liu, Ying, Liu, Zhenguo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333870/
https://ncbi.nlm.nih.gov/pubmed/30687016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00529
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