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Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors

Affective disorders arise from abnormal responses of the brain to prolonged exposure to challenging environmental stimuli. Recent work identified the orphan receptor GPR158 as a molecular link between chronic stress and depression. Here we reveal a non-canonical mechanism by which GPR158 exerts its...

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Détails bibliographiques
Publié dans:Neuropsychopharmacology
Auteurs principaux: Orlandi, Cesare, Sutton, Laurie P., Muntean, Brian S., Song, Chenghui, Martemyanov, Kirill A.
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333837/
https://ncbi.nlm.nih.gov/pubmed/30546127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0238-y
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