Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer

The effective treatment of cerebral metastases from HER2-positive breast cancer remains an unmet need. Recent studies indicate that activated astrocytes and brain endothelial cells exert chemoprotective effects on cancer cells through direct physical interaction. Here we report that the endothelin a...

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Foilsithe in:NPJ Breast Cancer
Main Authors: Askoxylakis, Vasileios, Ferraro, Gino B., Badeaux, Mark, Kodack, David P., Kirst, Isabelle, Shankaraiah, Ram C., Wong, Christina S. F., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
Ábhair:
Brief Communication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333771/
https://ncbi.nlm.nih.gov/pubmed/30675514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-018-0100-8
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