No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study

BACKGROUND: Studies have shown strong positive associations between serum urate (SU) levels and chronic kidney disease (CKD) risk; however, whether the relation is causal remains uncertain. We evaluate whether genetic data are consistent with a causal impact of SU level on the risk of CKD and estima...

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Bibliografske podrobnosti
izdano v:PLoS Med
Main Authors: Jordan, Daniel M., Choi, Hyon K., Verbanck, Marie, Topless, Ruth, Won, Hong-Hee, Nadkarni, Girish, Merriman, Tony R., Do, Ron
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333326/
https://ncbi.nlm.nih.gov/pubmed/30645594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002725
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