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Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines

A tetrakis(phenolato) Ti(iv) complex was synthesized in racemic and optically pure form, exhibiting high hydrolytic stability, and similar cytotoxicity for all stereochemical forms on HT-29 and A2780 cancer cells. Higher activity of the racemate on drug-resistant A2780cp and A2780adr lines implies a...

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Detalhes bibliográficos
Publicado no:RSC Adv
Main Authors: Miller, Maya, Tshuva, Edit Y.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333245/
https://ncbi.nlm.nih.gov/pubmed/30713687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ra08925f
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