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Compressive force induces reversible chromatin condensation and cell geometry–dependent transcriptional response

Fibroblasts exhibit heterogeneous cell geometries in tissues and integrate both mechanical and biochemical signals in their local microenvironment to regulate genomic programs via chromatin remodelling. While in connective tissues fibroblasts experience tensile and compressive forces (CFs), the role...

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Détails bibliographiques
Publié dans:Mol Biol Cell
Auteurs principaux: Damodaran, Karthik, Venkatachalapathy, Saradha, Alisafaei, Farid, Radhakrishnan, A. V., Sharma Jokhun, Doorgesh, Shenoy, Vivek B., Shivashankar, G. V.
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333178/
https://ncbi.nlm.nih.gov/pubmed/30256731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-04-0256
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