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Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice

Parasitic flatworms cause serious infectious diseases that affect humans and livestock in vast regions of the world, yet there are few effective drugs to treat them. Thioredoxin glutathione reductase (TGR) is an essential enzyme for redox homeostasis in flatworm parasites and a promising pharmacolog...

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Detalles Bibliográficos
Publicado en:Molecules
Main Authors: Pasquet, Vivian, Bisio, Hugo, López, Gloria V., Romanelli-Cedrez, Laura, Bonilla, Mariana, Saldaña, Jenny, Salinas, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6332120/
https://ncbi.nlm.nih.gov/pubmed/26132905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules200711793
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